Cancer cell shape sorter wins Pioneer award

Professor Vesselin Paunov and Dr Leigh Madden at the Faculty of Science and Engineering of the University of Hull and Dr David Allsup, a clinical hematologist consultant from the Queens Oncology Centre at Castle Hill Hospital, were recently granted the very prestigious Pioneer Award from Cancer Research UK to work on a novel in-vitro technology for removal of malignant blood cancer cells from blood samples of acute myeloma leukaemia (AML) patients based on bioimprinting and cell shape recognition.

Bioimprints are physical copies of the cell surface produced by casting the myeloblast cells with polymers and other materials. The cell shape recognition is based on the increased area of contact of target myeloblast cells with their negative replica on the bioimprinted surface.

This cell shape recognition technology would potentially allow Paunov’s team to develop a device which can separate in-vitro the malignant myeloblasts from the normal white blood cells. Such cell shape sorter could deplete further the blood of AML patients from myeloblasts after chemotherapy which may potentially improve their prognosis and reduce AML relapses based on the counts of minimal residual disease.

Our Hull team was one of the five awarded the Pioneer Award at this round along with other teams from the Universities of Cambridge, Oxford, Manchester and the Institute of Cancer Research – London.

Read more about this on the Cancer Research UK science blog.

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